Research and clinical trials by the Department of Respiratory and Sleep Medicine at St George Hospital, Sydney have found a high level of acceptance and tolerance among patients and concluded that the SomnoMed MAS™ is a viable alternative to CPAP in the treatment of OSA in a significant proportion of patients across all grades of OSA severity ^1,2.

Comparison of custom-made and thermoplastic oral appliance

From the department of Otorhinolaryngology, Head and Neck Surgery, Pulmonary
Medicine and Dentistry, Antwerp University Hospital, University of Antwerp, Antwerp, Belgium; and the department of Orthodontics and Pulmonary Medicine, Ume University, Ume, Sweden

Position paper on the use of mandibular advancement devices in adults with sleep-related breathing disorders (Requires PDF reader.)

Susanne Schwarting & Ulrich Huebers & Markus Heise &
Joerg Schlieper & Andreas Hauschild

A position paper of the German Society of Dental Sleep Medicine (Deutsche Gesellschaft Zahnaerztliche Schlafmedizin, DGZS)

Oral Appliances for Snoring and Obstructive Sleep Apnea: A Review (Requires PDF reader.)

Kathleen A. Ferguson, Rosalind Cartwright, Robert Rogers, Wolfgang Schmidt-Nowara

Division of Respirology, University of Western Ontario, London, Ontario, Canada, Department of Behavioral Sciences, Rush University Medical Center, Chicago, IL, Department of Dental Medicine, St. Barnabas Medical Center, Gibsonia, PA, University of Texas Southwestern, Sleep Medicine Associates of Texas, Dallas, TX

Oropharyngeal collapse predicts treatment response with oral appliance therapy in obstructive sleep apnea. (Requires PDF reader.)

Ng AT, Qian J, Cistulli PA
Department of Respiratory Medicine, St. George Hospital, Belgrave Street, Kogarah, NSW 2217, Australia.

We conducted an evidence-based review of literature regarding
use of oral appliances (OAs) in the treatment of snoring and obstructive
sleep apnea syndrome (OSA) from 1995 until the present. Our structured search revealed 141 articles for systematic scrutiny, of which 87 were suitable for inclusion in the evidence base, including 15 Level I to II randomized controlled trials and 5 of these trials with placebo-controlled treatment.

SLEEP. 2006;29(5)666-71.

Oral appliance therapy reduces blood pressure in obstructive sleep apnea: a randomized, controlled trial.

Gotsopoulos H, Kelly JJ, Cistulli PA.
Department of Respiratory & Sleep Medicine, St George Hospital, The University of New South Wales, Sydney Australia.

Sleep. 2004 Aug 1;27(5):934-41.

Treatment of the Obstructive Sleep Apnea/Hypopnea Syndrome: the Effect on Blood Pressure.

Douglas NJ.
Respiratory Medicine, University of Edinburgh, Scotland, UK

Comment on Gotsopoulos H et al. Oral appliance therapy reduces blood pressure in obstructive sleep apnea: a randomized controlled trial.

Sleep. 2004;27(5):934-41.

Effect of Oral Appliance Therapy on Upper Airway Collapsibility in Obstructive Sleep Apnea.

Ng AT, Gotsopoulos H, Qian J, Cistulli PA
Department of Respiratory Medicine, St. George Hospital, Belgrave Street, Kogarah, NSW 2217, Australia.

Am J Respir Crit Care Med. 2003 Jul 15;168(2):238-41